- 《英文msh词典》Neural Adhesion Molecule L1
- [入口词] Neural Adhesion Molecule L1
- [主题词] Neural Cell Adhesion Molecule L1
- [英文释义] A member of the immunoglubulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains,five fibronectin domains,a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain,and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion,neuronal migration,axonal growth and pathfinding,and myelination.
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